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What is G-6-S??

By Jessica Howard, of Jekuthiel's Nubians

The full name for G-6-S is:

Glucosamine-6-Sulfatase Deficiency or Caprine Mucopolysaccharidosis-IIID

It was first discovered in Nubians by Michigan State University in the 1980's.

This is a simple recessive gene (meaning goats with only one copy appear normal) that can be breed out in a few generations.

There are Affected (has two copies of the defective gene & has symptoms), Carriers (has one copy of the defective and one copy of the normal gene & no symptoms), and then we have the Normal (has two copies of the normal gene) goats.

Symptoms of Affected animals can include:

    * Small Stature
    * Lack of Muscling
    * Immune System Problems
    * Heart Problems
    * Reproductive Problems
    * Death by 3 to 4 years of age

Here's an example of how this works:

Let's say the affected gene is an "X" and a normal gene's a "Y".
Affected goats would have two X's (XX)
Carriers goats would have an "X" & a "Y" (XY)
Normal goats have two Y's (YY)
Parents give one of their two genes to their kids.


An Affected (XX) bred to an Affected (XX) will produce:
100% Affected (XX)

An Affected (XX) bred to a Carriers (XY) will produce:
50% Affected (XX) -- 50% Carriers (XY)

A Carriers (XY) bred to a Carriers (XY) will produce:
25% Affected (XX) -- 50% Carriers (XY) -- 25% Normal (YY)

A Carriers (XY) bred to a Normal (YY) will produce:
50% Carriers (XY) -- 50% Normal (YY)

A Normal (YY) bred to a Normal (YY) will produce:
100% Normal (YY)

G-6-S testing:

All samples must be accompanied by a submission form (http://tvmdl.tamu.edu/forms/s_DS_F0009B_Cash_Sales_Submittal_Form_fillable.pdf) and payment.

Current pricing for G-6-S testing is $36/in state or $42/out of state. Plus an accession fee of $6/in state or $7.50/out of state. (please check website for updated info)
You need 1-2 ml EDTA blood (whole blood in a purple top tube) or 2 straws of semen to do this test.
When shipping from Canada, it is advisable to first obtain a copy of TVMDL's import permit for blood samples.
Make sure you check out their shipping regulations on their website, too!

I just found this company where you can order the purple top tubes in quantities of less then 100!!
Light Livestock Equipment & Supply

More Information:

The TVMDL website http://tvmdl.tamu.edu/
(Choose "Testing" from the menu at the top of the screen, then Molecular Diagnostics under Fee Schedule to the left. It is listed as G6S mutation, Caprine.)
Direct link to TVMDL contact information page to get more info.

You can view a listing of G-6-S tested Nubians on NubianTalk. It's NOT a complete list as it is only as complete as the number of people who enter the results of their goats. Many breeders don't even test for it, or aren't willing to sacrifice 2 straws of their 'rare' semen to find out the status of the older bucks.
You will need to join the list and then select "Nubian listing for G6S testing" under the Database section.


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Last revised: March 24, 2014

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